What is caffeine anhydrous powder?
Caffeine anhydrous powder (CAS: 58-08-2) is the crystalline dehydrated form of caffeine. Unlike natural caffeine in tea or coffee, it is highly concentrated and stable, making it an essential laboratory reagent.
CristalChem supplies Caffeine Anhydrous Powder 99% – buy now at CristalChem with safe worldwide delivery to Ireland, UK, Canada, Australia, Spain, New Zealand, Germany, Sweden, Belgium, France, Latvia and the Netherlands.
Properties of caffeine crystalline compound
| Parameter | Value |
|---|---|
| Chemical formula | C8H10N4O2 |
| Molecular weight | 194.19 g/mol |
| Appearance | White crystalline solid |
| Melting point | 235–238 °C |
| Solubility | Soluble in hot water, ethanol, chloroform |

Applications of caffeine crystalline reagent in research
Analytical chemistry
Anhydrous caffeine is a reference compound in HPLC, UV-Vis, IR and NMR analyses.
Educational experiments
Universities use caffeine crystalline powder to teach crystallisation and solubility, often comparing it with caffeine extracted from natural sources.
Biochemical studies
High-purity caffeine is studied under controlled laboratory conditions to understand alkaloid metabolism.
For related reagents see:
- Benzocaine Powder – laboratory properties
- Lidocaine HCL Powder – analytical applications
- Levamisole HCL Powder – research reagent
- Phenacetin Powder – educational experiments
- Paracetamol Powder – crystalline compound
Market and regulations
EU and UK
Caffeine crystalline powder is a laboratory reagent, supplied under REACH/CLP guidelines.
Canada and Australia
Requires WHMIS-compliant SDS in Canada and Safe Work Australia documentation in Australia.
Other regions
Laboratories in Ireland, Germany, Spain, France, Netherlands, Sweden, Belgium, Latvia and New Zealand regularly import caffeine crystalline reagent for research use.
➡ PubChem – Caffeine
➡ ChemSpider – Caffeine
➡ NIST Chemistry WebBook – Caffeine
➡ ChEBI – Caffeine
➡ ECHA – Substance Info Caffeine
CristalChem guarantees safe worldwide delivery with compliance and full documentation.
Safe handling of caffeine crystalline reagent
Laboratory workers use gloves, goggles and protective clothing. Work is conducted in ventilated spaces to avoid inhalation of fine powder.

Experiments & Tips
🧪 Classic experiment
Compare the melting point of caffeine extracted from tea leaves with high-purity caffeine anhydrous powder.
👉 Result: impurities in the crude extract lower and broaden the melting range. This is a classic teaching experiment in organic analysis classes.
💡 Scientific curiosity
Crystalline caffeine is sometimes used in NMR laboratories as a quick calibration standard. It is stable and produces consistent signals, making it ideal for instrument checks.
💡 Practical tip
Always store caffeine anhydrous powder in tightly sealed, dry containers. Even slight humidity can cause clumping, leading to weighing errors and inconsistent experimental results.
💡 Extra fact
The molecular structure of caffeine resembles purines (adenine and guanine). This similarity explains why it competes with adenosine in biological systems, blocking its receptors and producing a stimulating effect. In research, this property is useful for modeling ligand–receptor interactions.
FAQ – Caffeine Anhydrous
Is caffeine anhydrous powder legal?
Yes, caffeine crystalline reagent is legal for laboratory and R&D use.
How can I buy caffeine anhydrous powder online?
You can buy caffeine anhydrous powder online directly at CristalChem in 100 g to 1 kg packs.
➡ Caffeine Anhydrous Powder 99% – buy now at CristalChem
Do you deliver caffeine crystalline reagent to Ireland, UK, Canada and Australia?
Yes, CristalChem supplies caffeine Ireland, caffeine UK, caffeine Canada and caffeine Australia, with safe worldwide delivery.
What purity is available?
CristalChem offers high-purity caffeine crystalline powder (≥99%) for R&D.
Summary
Caffeine anhydrous crystalline powder (CAS: 58-08-2) is a stable, high-purity laboratory reagent widely used in education, spectroscopy and biochemical studies.
CristalChem provides caffeine crystalline reagent for sale with guaranteed safe worldwide delivery to Ireland, UK, EU, Canada, Australia and beyond.
➡ Caffeine Anhydrous Powder 99% – buy now at CristalChem
Chemical Research Writer at CristalChem Academy. Passionate about chemistry, R&D, and turning laboratory insights into global wellness and industrial innovations.