Introduction
Lidocaine HCl Crystalline Powder (CAS 6108-05-0) is a benchmark local anesthetic for modern R&D, pharma, tattoo, dental and dermo-aesthetic applications. The crystalline form ensures stability, precise handling and reproducible lab results. At CristalChem we provide high-purity Lidocaine HCl with safe worldwide delivery to teams across USA, Canada, UK, Ireland, Germany, France, Spain, Italy, Sweden, Estonia, Latvia, Romania, Bulgaria, the Netherlands, Australia, New Zealand, Mexico and beyond.

Molecular structure of Lidocaine HCl crystalline powder molecular structure CAS 6108-05-0 CristalChem.
Properties & Forms
- CAS: 6108-05-0
- Molecular formula: C14H23ClN2O
- Molecular weight: 288.81 g/mol
- IUPAC: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride
- Appearance: white crystalline powder
- Melting point: ~80–82 °C
- pKa: ~7.9 | logP: ~2.3
- Solubility: highly soluble in water/ethanol; limited in oils
- Storage: airtight container, dry, protected from light
Reference data: PubChem: lidocaine hydrochloride (search), NIST WebBook: lidocaine (entry), ChemSpider: CAS 6108-05-0 (search), ECHA CLP: lidocaine hydrochloride (search).
Available forms for labs and pre-production
- Crystalline powder – stable and versatile for QC and formulation screening.
- Mesh-graded powder – improved blend uniformity.
- Fluffy powder – lightweight for rapid aqueous dissolution.
Compare with other anesthetic reagents from CristalChem: Benzocaine, Procaine, and cooling agents like Menthol. For general safety handling see our SDS Guide.

Laboratory vial & doypack with Lidocaine HCl crystalline powder CAS 6108-05-0 CristalChem
Applications in Industries
Tattoo & Piercing
Studios in USA, UK, Germany, Spain, Canada and Australia rely on Lidocaine HCl Crystalline Powder to formulate pre-session numbing creams (4–5%), quick-acting sprays and soothing aftercare gels that increase client comfort and studio efficiency.
Dental & Medical
- Topical dental gels applied before minor procedures.
- Injectable solutions (R&D context) for local anesthesia in oral/dermal practice.
- Dermatology – biopsies, minor procedures with topical anesthetic pre-treatment.
Aesthetic & Wellness
- Dermal fillers (many HA fillers contain lidocaine for comfort).
- Laser/epilation creams for clinics in France, Italy, Sweden.
- Cooling wellness sprays (menthol + lidocaine) for sports recovery in New Zealand and Australia.
Pharma & OTC
OTC topical products (2–4% lidocaine) are widely available in Germany, UK, Canada, USA. Regulatory status varies (OTC vs Rx-only). Always check ECHA CLP entry/search and local regulations (e.g., FDA search: lidocaine topical, EMA search: lidocaine).
Market Outlook & Global Trends
Local anesthetics are on a steady growth trajectory. Market intelligence indicates rising demand driven by dermo-aesthetics, dental services, tattoo culture and OTC self-care. See: Verified Market Reports – local anesthetics (search), Statista – local anesthetics (search), ResearchAndMarkets – local anesthetics (search).
⚠️ Important Legal & Safety Notice — Read Before Proceeding
The procedures and examples below are for informational and educational purposes only. They are not production-ready instructions or medical advice. Experiments and prototyping should be carried out only by qualified professionals in properly equipped facilities, in compliance with local regulations. Quantities shown are illustrative prototypes. Before any commercial use, perform risk assessments, stability/tox tests and obtain required approvals (FDA/EMA/ECHA/local laws). CristalChem accepts no liability for misuse or accidents.
Experiments & R&D Tips
Experiment 1 — Solubility Profiling
Objective: Compare solubility of Lidocaine HCl in water, ethanol (50–70%), and glycerol.
Outcome: Fastest dissolution in water; ethanol co-solvent enhances dermal delivery in topical prototypes.
Experiment 2 — Stability Screening
Objective: Assess crystalline stability at 25/40/60 °C (dark vs light).
Outcome: Stable up to ~40 °C when protected from light/moisture; use amber vials and desiccants.
Experiment 3 — Prototype Dermo Spray
Objective: Quick topical prototype for R&D.
Method: Dissolve 2 g Lidocaine HCl in 50 ml ethanol + 50 ml purified water; filter (0.22 µm) into spray vial.
Note: For lab evaluation only; not a finished product.
Experiment 4 — Compatibility Check (with Epinephrine)
Objective: Observe color/stability changes in lidocaine + epinephrine lab mix.
Tip: Protect from light; monitor oxidation.
Lab & Source Tips
- Store powder airtight; minimize humidity exposure.
- Use amber glass for solutions; label with batch/date.
- Combine with cooling agents like Menthol for wellness prototypes.
- Cross-compare with Benzocaine and Procaine in QC tests.
- Review literature: ScienceDirect – lidocaine topical anesthetic (search), ResearchGate – lidocaine hydrochloride (search).
- Follow safety best practices from our SDS Guide.

Dermatology lab applying anesthetic Lidocaine HCl anesthetic cream CAS 6108-05-0 CristalChem.
Business Opportunities
Demand spans pharma, aesthetics and tattoo markets. Brands can turn Lidocaine HCl Crystalline Powder into high-value OTC topicals (where allowed), clinic-use gels, or recovery kits. Market references: Verified Market Reports (search), Statista (search), ResearchAndMarkets (search), compound data at PubChem, NIST WebBook, ChemSpider.
Conclusion & Calls to Action
Lidocaine HCl Crystalline Powder (CAS 6108-05-0) connects science with real-world outcomes across USA, Canada, UK, Ireland, Germany, France, Spain, Italy, Sweden, Estonia, Latvia, Romania, Bulgaria, Netherlands, Australia, New Zealand, Mexico. For labs and innovators seeking reliable quality with safe worldwide delivery, CristalChem is a trusted partner.
- ✅ Buy Lidocaine (base) – safe worldwide delivery
- ✅ Order Lidocaine in Bulk – fast global shipping
- ✅ Shop Lidocaine for R&D – pharma & aesthetics
Internal Linking (CristalChem Academy)
- Benzocaine – product page
- Procaine – product page
- Menthol – product page
- Caffeine Anhydrous – product page
- Benzocaine manufacturing – academy article
- SDS Guide – academy article
Disclaimer: This article is for informational and educational purposes only. It is not production or medical advice. All experiments must be conducted by qualified personnel under proper regulatory and safety standards. CristalChem disclaims liability for misuse or accidents.
Cristina
Chemical Research Writer at CristalChem Academy. Passionate about chemistry, R&D, and turning laboratory insights into global wellness and industrial innovations.